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Sensitivity of the STAT-VIEW rapid self-test and implications for use during acute HIV infection


Author
Boukli et al.

Publication year
2017

Country

Type of approach
n/a

Type of assistance
Unassisted

Specimen
Fingerstick/whole blood

Study population
People living with HIV: People living with HIV

Study design
Feasibility/acceptability

Sample size
40

UNAIDS HIV prevalence (2017)
0.2 [0.2 - 0.2]

Methodology
Individuals tested at Saint-Antoine Hospital (Paris, France) with negative or indeterminate western blot results and detectableHIV-RNA were included. Rapid tests were performed retrospectively on stored serum. Patients with and without reactive rapid tests were compared, while probability of having a reactive test was modelled across infection duration using logistic regression.

Summary of findings
Of the 40 patients with acute HIV infection (AHI), 23 (57.5%) had a reactive STAT-VIEW rapid test. Patients with non-reactive versus reactive tests had a significantly shorter median time since infection (p=0.01), time since onset of symptoms (p=0.009), higher proportion with Fiebig stage III versus IV (p=0.003), negative western blot results (p=0.007), higher HIV-RNA levels (p=0.001) and lower CD4+ and CD8+ cell count (p=0.03, p<0.001, respectively). When examining sensitivity over the course of AHI duration, the probability of HIV detection was 75.5% at 5 weeks from HIV transmission. The INSTI provided similar results with respect to proportion of reactive tests (62.5%), determinants for non-reactive test and probability of HIV detection at 5 weeks of infection (85.0%).

Acceptability
n/a

Acceptability details
n/a

Willingness to pay
n/a

Willingness to pay details
n/a

Sensitivity
n/a

Specificity
n/a

Concordance
n/a

HIV positivity
n/a

Accuracy details
23 (57.5%) of HIV-positive patients, with acute HIV infection, had a reactive STAT-VIEW rapid test.The probability of HIV detection was 75.5% at 5 weeks from HIV transmission. The INSTI provided similar results with respect to proportion of reactive tests (62.5%), determinants for non-reactive test and probability of HIV detection at 5 weeks of infection (85.0%).

Social harm
n/a

Linkage to prevention, care and treatment
n/a


Study status
Completed